Recombinant Human IL-17(IL-17A)
|Cat No.||Size||Price||Add Cart|
|HIM-I17a-0010||10ug||$ 82.00||Add Cart|
|HIM-I17a-0100||100ug||$ 725.00||Add Cart|
|HIM-I17a-1000||1000ug||$ 3585.00||Add Cart|
• Expression of Human Proteins in Human Cells
• Extreme low Endotoxin
• High Purity
• Animal Free and Xeno Free
• Tag Free
Source: Human cells derived
Structure: Glycosylated monomer
Purity: >95% by SDS-PAGE
Endotoxin Level: <0.5EU/ug
Molecular Weight: 30-35kDa
Formulation: Lyophilized from a 0.2μm filtered solution in PBS without carrier protein
The activity was measured by its ability to induce IL-6 expression in the NHDF adult fibroblasts.
Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -80°C under sterile conditions after reconstitution.
IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles. IL-17(IL-17A) is a homodimer of two 136 amino acid chains that are secreted by activated T cells. IL-17A is expressed by activated Th17 cells. IL-17A induces stromal cells to produce proinflammatory and hematopoietic cytokines. It also enhances the surface expression of ICAM1 (intracellular adhesion molecule 1) in fibroblasts.
Bettelli E, et al. (2008) Nature 453,1051-1057.
Cua DJ, et al. (2010) Nat. Rev. Immunol. 10, 479.
Fossiez F, et al. (1996) J. Exp. Med. 183, 2593-2603.