Recombinant Human IL-17F
|Cat No.||Size||Price||Add Cart|
|HIM-I17f-0010||10ug||$ 82.00||Add Cart|
|HIM-I17f-0100||100ug||$ 725.00||Add Cart|
|HIM-I17f-1000||1000ug||$ 3538.00||Add Cart|
• Expression of Human Proteins in Human Cells
• Extreme low Endotoxin
• High Purity
• Animal Free and Xeno Free
• Tag Free
Source: Human cells derived
Structure: Glycosylated monomer
Purity: >95% by SDS-PAGE
Endotoxin Level: <0.5EU/ug
Molecular Weight: 38kDa
Formulation: Lyophilized from a 0.2μm filtered solution in PBS without carrier protein
The activity was measured by its ability to induce IL-6 expression in the NHDF adult fibroblasts.
Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -80°C under sterile conditions after reconstitution.
IL-17F is a member of IL-17 family of structurally- related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles. IL-17F is a homodimer of two 133 amino acid chains that are secreted by activated CD4+ T cells and activated monocytes. The biological activities mediated by IL-17F are similar to those of IL-17. IL-17F stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony stimulating factor. It can also regulate cartilage matrix turnover, stimulate PBMC and T cell proliferation, and inhibit angiogenesis.
Bettelli E, et al. (2008) Nature 453,1051-1057.
Shen F, et al. (2008) Cytokine 41:92.
Starnes T, et al. (2001) J. Immunol. 167,4137- 4140.