Hu-Cytokines

Recombinant Human IL-17F

Cat No. Size Price Add Cart
HIM-I17f-0010 10ug $ 82.00 Add Cart
HIM-I17f-0100 100ug $ 725.00 Add Cart
HIM-I17f-1000 1000ug $ 3538.00 Add Cart

Product Specifications

•      Expression of Human Proteins in Human Cells

•      Extreme low Endotoxin

•      High Purity

•      Animal Free and Xeno Free

•      Tag Free

 

Source: Human cells derived

Structure: Glycosylated monomer

Purity: >95% by SDS-PAGE

Endotoxin Level: <0.5EU/ug

Molecular Weight: 38kDa

Formulation: Lyophilized from a 0.2μm filtered solution in PBS without carrier protein

 

Activity Assay

The activity was measured by its ability to induce IL-6 expression in the NHDF adult fibroblasts.

 

Reconstitution

Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.

 

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -80°C under sterile conditions after reconstitution.

 

Protein Description

IL-17F is a member of IL-17 family of structurally- related cytokines that share a highly conserved C-terminal region, but  differ  from  one  another in their N-terminal regions and in their distinct biological  roles.  IL-17F  is  a  homodimer  of  two 133 amino acid chains that are secreted by activated CD4+ T cells and activated monocytes. The biological activities mediated by IL-17F are similar to those of IL-17. IL-17F stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony stimulating factor. It can also regulate cartilage matrix turnover, stimulate PBMC and T cell proliferation, and inhibit angiogenesis.

 

References

Bettelli E, et al. (2008) Nature 453,1051-1057.

Shen F, et al. (2008) Cytokine 41:92.

Starnes T, et al. (2001) J. Immunol. 167,4137- 4140.