Recombinant Human IL-23

Cat No. Size Price Add Cart
HCT-I23-0010 10ug $ 273.00 Add Cart
HCT-I23-0100 100ug $ 1635.00 Add Cart
HCT-I23-1000 1000ug $ 9882.00 Add Cart

Product Specifications

•      Expression of Human Proteins in Human Cells

•      Extreme low Endotoxin

•      High Purity

•      Animal Free and Xeno Free

•      Tag Free


Source: Human cells derived

Structure: Glycosylated heterodimer

Purity: >95% by SDS-PAGE

Endotoxin Level: <0.5EU/ug

Molecular Weight: 55kDa

Formulation: Lyophilized from a 0.2μm filtered solution in PBS without carrier protein


Activity Assay

The activity was measured by its ability to induce the IL-17 expression in murine splenocytes.



Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.


Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -80°C under sterile conditions after reconstitution.


Protein Description

IL-23 is  a  heterodimeric cytokine composed of two subunits: a unique p19 subunit, and a p40 subunit that is shared with IL-12. IL-23 is secreted by activated dendritic cells and macrophages. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T cells and promotes production of proinflammatory cytokines, such as IFNγ and IL-17. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.



Oppmann B, et al. (2000) Immunity 13,715-725.

Lupardus PJ, et al. (2008) J. Mol. Biol. 382,931-941.

Aggarwal S, et al. (2003) J. Biol. Chem. 278,1910.