Recombinant Human IL-28A
|Cat No.||Size||Price||Add Cart|
|HIN-I28a-0010||10ug||$ 190.00||Add Cart|
|HIN-I28a-0100||100ug||$ 1400.00||Add Cart|
|HIN-I28a-1000||1000ug||$ 4251.00||Add Cart|
• Expression of Human Proteins in Human Cells
• Extreme low Endotoxin
• High Purity
• Animal Free and Xeno Free
• Tag Free
Source: Human cells derived
Structure: Glycosylated monomer
Purity: >95% by SDS-PAGE
Endotoxin Level: <0.5EU/ug
Molecular Weight: 24kDa
Formulation: Lyophilized from a 0.2μm filtered solution in PBS without carrier protein
The activity was measured by its anti-virus function in A549 cells (human lung adenocarcinoma epithelial cell line) infected with encephalomyocarditis (EMC) virus.
Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -80°C under sterile conditions after reconstitution.
IL-28A, also named interferon λ2 (IFNλ2), belongs to the type III interferon protein family, which is distinct from the type I IFNs. IL-28A is induced by virus infection or double stranded RNA. IL-28A acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. IL-28A has antiviral, antitumour and immunomodulatory activities, plays a critical role in the antiviral host defense, predominantly in the epithelial tissues.
Donnelly RP, et al. (2010) J. Interferon Cytokine Res. 30,555-564.
Sheppard P, et al. (2003) Nat. Immunol. 4, 63-68.