Recombinant Human Noggin

Cat No. Size Price Add Cart
HST-NG-0010 10ug $ 105.00 Add Cart
HST-NG-0100 100ug $ 735.00 Add Cart
HST-NG-1000 1000ug $ 3270.00 Add Cart

Product Specifications

•      Expression of Human Proteins in Human Cells
•      Extreme low Endotoxin
•      High Purity
•      Animal Free and Xeno Free
•      Tag Free
Source: Human cells derived
Structure: Glycosylated monomer
Purity: >95% by SDS-PAGE
Endotoxin Level: <0.5EU/ug
Molecular Weight: 65kDa
Formulation: Lyophilized from a 0.2μm filtered solution in PBS without carrier protein

Activity Assay

The activity was measured by the inhibition of BMP-4 induced alkaline phosphatase production in the ATDC-5 cell line (Mouse chondrogenic cell line).


Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -80°C under sterile conditions after reconstitution.

Protein Description

Noggin belongs to a group of diffusible proteins that bind to ligands of the TGF-β family, and regulate their activity by inhibiting their access to signaling receptors. Noggin is expressed in defined areas of the adult central nervous system and peripheral tissues such as lung, skeletal muscle and skin. Noggin has been shown to modulate the activities of other BMPs, which is required for growth and patterning of the neural tube and somite, and essential for cartilage morphogenesis and joint formation. Noggin also inhibits chondrocyte differentiation through its interaction with GDF5.


Schwaerzer GK, et al. (2012) J. Bone Miner. Res. 27,429-442.
Groppe J, et al. (2002) Nature 420,636-642.
Brunet LJ, et al. (1998)  Science 280,1455