Hu-Cytokines

Recombinant Human OSM

Cat No. Size Price Add Cart
HST-O-0010 10ug $ 185.00 Add Cart
HST-O-0100 100ug $ 1025.00 Add Cart
HST-O-1000 1000ug $ 3685.00 Add Cart

Product Specifications

•      Expression of Human Proteins in Human Cells

•      Extreme low Endotoxin

•      High Purity

•      Animal Free and Xeno Free

•      Tag Free

 

Source: Human cells derived

Structure: Glycosylated monomer

Purity: >95% by SDS-PAGE

Endotoxin Level: <0.5EU/ug

Molecular Weight: 30kDa

Formulation: Lyophilized from a 0.2μm filtered solution in PBS without carrier protein

 

Activity Assay

The activity was measured by its ability to stimulate the proliferation of human TF-1 cells (human erythroleukemic indicator cell line).

 

Reconstitution

Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.

 

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -80°C under sterile conditions after reconstitution.

 

Protein Description

Oncostatin M (OSM) is a 30 kDa secreted cytokine belonging to the Interleukin 6 family. OSM inhibits the proliferation of a number of tumor cell lines. It also stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. OSM plays crucial roles in inflammation, neuroprotection, hematopoiesis, metabolism and development.

 

References

Malik N, et al. (1989) Mol. Cell. Biol. 9, 2847-2853.

Rose TM, et al. (1991) Proc. Natl. Acad. Sci. U.S.A.88,8641-8645.