Recombinant Human PDGFbb

Cat No. Size Price Add Cart
EME-PFb-0010 10ug $ 195.00 Add Cart
EME-PFb-0100 100ug $ 845.00 Add Cart
EME-PFb-1000 1000ug $ 4125.00 Add Cart

Source: E. coli derived
Structure: Disulfide linked homodimer
Purity: >95% by SDS-PAGE
Endotoxin Level: <1EU/ug
Molecular Weight: 12.3kDa (monomer)
Formulation: Lyophilized from a 0.2μm filtered solution in 10mM acetic acid without carrier protein

Activity Assay

The activity was measured by its ability to stimulate   the proliferation of 3T3 mouse fibroblast cells.


Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 10mM acetic acid containing 0.1% endotoxin-free recombinant human serum albumin.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution.3 months, -20 to -80°C under sterile conditions after reconstitution.

Protein Description

PDGF is not one molecule but three, each a dimeric combination of two distinct but structurally related peptide chains designated A and B. The dimeric isoforms PDGF­aa, ab and bb are differentially expressed in various cell types and their effects are mediated through two distinct receptors, termed α and β. The PDGFs plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. They are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development.


Andrae J, et al. (2008) Genes Dev. 22,1276-1312.
Shim AH, et al. (2010) Proc. Natl. Acad. Sci. U.S.A. 107,11307-11312.