Growth Factors

Recombinant Human BMP-7

Cat No. Size Price Add Cart
HST-B7-0010 10ug $ 208.00 Add Cart
HST-B7-0100 100ug $ 1491.00 Add Cart
HST-B7-1000 1000ug $ 7455.00 Add Cart

Product Specifications

Source: Human cells derived
Structure: Glycosylated homodimer
Purity: >95% by SDS-PAGE
Endotoxin Level: <0.5EU/ug
Molecular Weight: 30-38kDa
Formulation: Lyophilized from a 0.2μm filtered solution in PBS without carrier protein

Activity Assay

The activity was measured by its ability to induce alkaline phosphatase production in the ATDC-5 cell line (Mouse chondrogenic cell line).

Reconstitution

Briefly  centrifuge  the  vial  before  opening.  It  is recommended to reconstitute the protein in sterile 4 mM  HCl  containing  at  least  0.1%  human  or bovine serum albumin.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -80°C under sterile conditions after reconstitution.

Protein Description

Bone morphogenetic protein 7 (BMP-7), also known as osteogenic protein 1 (OP1) is a member of transforming growth factor β family that includes more than 20 structurally related bone growth factors. BMP-7 plays an important role in cartilage and bone formation. It also plays a role in calcium regulation and kidney development. Mature human BMP-7 is usually a homodimer consisting of two antiparallel monomers of 139 amino acids. Dimerization is facilitated by a disulfide bridge formed between the monomer, which contains three intrachain disulfide bridges arranged in a cystine knot motif.

References 

Wang RN, et al. (2014)Genes& Diseases 1,87e105. Chen D, et al. (2004) Growth Factors 22:233.
Celeste AJ,  et  al.  (1990)Proc.  Natl. Acad.  Sci.U.S.A. 87,9843-9847.