Recombinant Human IL-3
|Cat No.||Size||Price||Add Cart|
|HCT-I3-0010||10ug||$ 205.00||Add Cart|
|HCT-I3-0100||100ug||$ 785.00||Add Cart|
|HCT-I3-1000||1000ug||$ 3245.00||Add Cart|
The activity was measured by its ability to stimulate the proliferation of human TF-1 cells (human erythroleukemic indicator cell line).
Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile PBS containing at least 0.1% human or bovine serum albumin.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -80°C under sterile conditions after reconstitution.
Interleukin-3 (IL-3) is belongs to hematopoietic growth factors. It is a secreted protein. IL-3 can improve the body's natural response to disease as part of the immune system. IL-3 stimulates the differentiation of multipotent hematopoietic stem cells into myeloid progenitor cells (as opposed to lymphoid progenitor cells where differentiation is stimulated by IL-7) as well as stimulates proliferation of all cells in the myeloid lineage (erythrocytes, megakaryocytes, granulocytes, monocytes, and dendritic cells) in conjunction with other cytokines, such as EPO, GM-CSF, TPO and IL-6. Additionally, IL-3 aids in embryo implantation and placental development, was found to be decreased both in pregnant women with antiphospholipid syndrome and in animal models of APS. IL-3 also participates in the response of the organism to various types of stress.
Yang YC, et al. (1986). Cell 47(1): 3-10.
Martinez-Moczygemba M, et al (2003). J. Allergy Clin. Immunol. 112 (4): 653–65.