Product Application: Recombinant Human FGF-8b
Primary Application:
- Developmental Biology: FGF-8b plays a crucial role in embryonic development, particularly in the formation of the brain, eyes, ears, and limbs.
- Stem Cell Research: It can be used to maintain the pluripotency of stem cells and to induce their differentiation into specific cell types.
- Tissue Engineering: FGF-8b can be used to promote tissue regeneration and repair, especially in neural tissues.
- Cancer Research: FGF-8b has been implicated in tumorigenesis and metastasis, making it a potential target for cancer therapy.
Specific Uses:
- Neural Tissue Regeneration: FGF-8b can be used to promote the regeneration of neural tissues, such as the brain and spinal cord.
- Drug Discovery: FGF-8b can be used as a target for drug development, particularly in the areas of neurodegenerative diseases and cancer.
- Basic Research: FGF-8b is a valuable tool for studying the mechanisms of embryonic development, cell proliferation, and differentiation.
Key Features and Benefits:
- High Purity and Low Endotoxin: Ensures optimal biological activity and minimal off-target effects.
- Recombinant Human FGF-8b: Ensures consistent quality and activity.
- Easy to Use: Lyophilized format allows for easy storage and reconstitution.
- Versatile: Can be used in a variety of applications, including research, drug development, and tissue engineering.
Summary: Recombinant Human FGF-8b is a valuable tool for researchers and scientists working in the fields of developmental biology, stem cell research, tissue engineering, and cancer research. It offers a versatile and effective way to manipulate cell growth and differentiation.
Welcome to the documentation download page. Below you'll find important documents related to our products, including Certificates of Analysis (COA), Data Sheets, Material Safety Data Sheets (MSDS), and more. These documents provide essential information for product use, safety, and technical specifications.
Product Specifications
Expression of Human Proteins in Human Cells
Extreme low Endotoxin
High Purity
Animal Free and Xeno Free
Tag Free
Structure: Glycosylated monomer
Purity: >95% by SDS-PAGE
Endotoxin Level: <0.5EU/ug
Molecular Weight: 35-45kDa
Formulation: Lyophilized from a 0.2μm filtered solution in PBS without carrier protein
Activity Assay
The activity was measured by its ability to stimulate the proliferation of 3T3 mouse fibroblast cells.
Reconstitution
Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -80°C under sterile conditions after reconstitution.
Protein Description
FGF-8b(FGF-8) is belonging to the FGF family, which is widely expressed during embryogenesis. There are four known alternate spliced forms of FGF-8: FGF-8a, FGF-8b, FGF-8e and FGF-8f. Proteins of this family play an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. FGF-8b is required for normal brain, eye, ear and limb development during embryogenesis. It is also required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-8b shows the strongest receptor affinity and oncogenic transforming capacity.
References
Gemel J, et al. (1996) Genomics 35,253-257.
Ornitz DM, et al. (1996) J. Biol. Chem. 271, 15292-15297.
Vantaggiato C, et al. (2011) Brain 134, 1808-1828.
Recombinant Human FGF-8b
- Brand: StemImmune LLC
- Product CAT#: HST-F8-0010 (10ug), HST-F8-0100 (100ug), HST-F8-1000 (1000ug)
- Availability: In Stock
Available Options
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Tags: Growth Factors