• Recombinant Human G-CSF

Product Application: Recombinant Human G-CSF

Primary Application:

  • Hematopoietic Stem Cell Mobilization: G-CSF is used to mobilize hematopoietic stem cells from the bone marrow into the peripheral blood, facilitating bone marrow transplantation procedures.
  • Neutropenia Treatment: It is used to treat neutropenia, a condition characterized by a low neutrophil count, often caused by chemotherapy or other medical treatments.
  • Stem Cell Research: G-CSF is a valuable tool for studying hematopoiesis and stem cell biology.

Specific Uses:

  • Bone Marrow Transplantation: G-CSF is administered to patients undergoing bone marrow transplantation to increase the number of stem cells available for transplantation.
  • Cancer Therapy: It can be used to reduce the severity of neutropenia caused by chemotherapy.
  • Research: G-CSF is widely used in research to study hematopoiesis, immune cell development, and stem cell biology.

Key Features and Benefits:

  • High Purity and Low Endotoxin: Ensures optimal biological activity and minimal off-target effects.
  • Recombinant Human G-CSF: Ensures consistent quality and activity.
  • Easy to Use: Lyophilized format allows for easy storage and reconstitution.
  • Versatile: Can be used in a variety of applications, including pre-clinical and research settings.

Summary: Recombinant Human G-CSF is a valuable therapeutic agent and research tool for managing neutropenia and mobilizing hematopoietic stem cells. It plays a crucial role in improving the outcomes of bone marrow transplantation and cancer therapy.

Welcome to the documentation download page. Below you'll find important documents related to our products, including Certificates of Analysis (COA), Data Sheets, Material Safety Data Sheets (MSDS), and more. These documents provide essential information for product use, safety, and technical specifications.

 

Product Specifications

  • Expression of Human Proteins in Human Cells
  • Extreme low Endotoxin
  • High Purity
  • Animal Free and Xeno Free
  • Tag Free

Source: Human cells derived
Structure: Glycosylated monomer
Purity: >95% by SDS-PAGE
Endotoxin Level: <0.5EU/ug
Molecular Weight: 21-25kDa
Formulation: Lyophilized from a 0.2μm filtered solution in PBS without carrier protein

Activity Assay

The activity was measured by its ability to stimulate the proliferation of murine M-NFS-60 cells (Mouse Myeloid Leukemia indicator cell line).

Reconstitution

Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -80°C under sterile conditions after reconstitution.

Protein Description

Granulocyte colony stimulating factor (G-CSF) is a hematopoietic growth factor belonging to the CSF family. G-CSF is mainly expressed in monocyte/macrophage lineage. It is also expressed in cells of mesodermal origin, including vascular endothelial cells, fibroblasts, and mesothelial cells. G-CSF acts in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages.

References

Nagata S et al. (1986) Nature 319,415-418.
Shirafuji N et al. (1989) Exp Hematol. 17,116-119.

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Recombinant Human G-CSF

  • Brand: StemImmune LLC
  • Product CAT#: HHM-GC-0010 (10ug), HHM-GC-0100 (100ug), HHM-GC-1000 (1000ug)
  • Availability: In Stock

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Tags: Hematopoietic cells growth factors