• Recombinant Human IFNγ

Product Specifications

  • Expression of Human Proteins in Human Cells
  • Extreme low Endotoxin
  • High Purity
  • Animal Free and Xeno Free
  • Tag Free
Source: Human cells derived
Structure: Glycosylated dimer
Purity: >95% by SDS-PAGE
Endotoxin Level: <0.5EU/ug
Molecular Weight: 21-25kDa

Formulation: Lyophilized from a 0.2μm filtered solution in PBS without carrier protein

 Activity Assay

IFNγ stimulates STAT1 phosphorylation in human lung microvascular endothelial cells. HLMVECs were serum starved in EBM-2 medium containing 2% FBS for overnight then treated with La IFNγ for 5 minutes at the indicated concentrations ranging from 0.5 to 500 ng/ml. Phosphorylated STAT1 (Tyr701) was detected by phosphor STAT1 antibody by Western Blot.

Reconstitution

Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -80°C under sterile conditions after reconstitution.

Protein Description

Interferon gamma (IFNγ) is a dimerized soluble cytokine that is the type II class of interferons. IFNγ signaling in antigen-presenting cells, and antigen-recognizing B and T lymphocytes, regulates the antigen-specific phases of the immune response.  IFNγ is critical for innate and adaptive immunity against viral, protozoal, bacterial infections. IFNγ is secreted by Th1, cytotoxic T cells, NKT cells and NK cells. IFNγ is particularly suitable for human CIK activation along with IL-2.

References

Gray PW, et al (August 1982). Nature 298 (5877): 859-63.
Jiang J et al. (2013) J Transl Med 11:83.

Stem Cells Studies
Description Immunotherapy DC-CIK Car-T and T-cells activation
Documentations
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Recombinant Human IFNγ

  • CAT#: HST-IFg-0010 (10ug), HST-IFg-0100 (100ug), HST-IFg-1000 (1000ug)
  • Availability: In Stock
  • $0.00


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