Product Application: Recombinant Human IL-10
Primary Application:
- Immunomodulation: IL-10 is a potent anti-inflammatory cytokine that can suppress the immune response.
- Autoimmune Disease Treatment: It is used to treat autoimmune diseases, such as Crohn's disease and ulcerative colitis.
- Transplantation: IL-10 can be used to prevent graft rejection in organ transplantation.
- Research: IL-10 is widely used in research to study immune regulation and inflammation.
Specific Uses:
- Autoimmune Disease Therapy: IL-10 can be used to treat autoimmune diseases, such as Crohn's disease, ulcerative colitis, and rheumatoid arthritis.
- Organ Transplantation: It can be used to prevent graft rejection after organ transplantation.
- Cancer Therapy: IL-10 can be used in combination with other therapies to treat certain types of cancer.
- Research: IL-10 is used to study the regulation of the immune response and inflammation.
Key Features and Benefits:
- High Purity and Low Endotoxin: Ensures optimal biological activity and minimal side effects.
- Recombinant Human IL-10: Guarantees consistent quality and activity.
- Easy to Use: Lyophilized format allows for easy storage and reconstitution.
- Versatile: Can be used in a variety of applications, including research, pre-clinical, and therapeutic settings.
In summary, Recombinant Human IL-10 is a valuable tool for researchers and clinicians working in the field of immunology. It offers a versatile and effective way to modulate the immune response and treat inflammatory diseases.
Welcome to the documentation download page. Below you'll find important documents related to our products, including Certificates of Analysis (COA), Data Sheets, Material Safety Data Sheets (MSDS), and more. These documents provide essential information for product use, safety, and technical specifications.
Product Specifications
- Expression of Human Proteins in Human Cells
- Extreme low Endotoxin
- High Purity
- Animal Free and Xeno Free
- Tag Free
Source: Human cells derived
Structure: Glycosylated monomer
Purity: >95% by SDS-PAGE
Endotoxin Level: <0.5EU/ug
Molecular Weight: 17kDa
Formulation: Lyophilized from a 0.2μm filtered solution in PBS without carrier protein
Activity Assay
The activity was measured by its ability to stimulate the proliferation of MC/9-2 cells (mouse master cell line).
Reconstitution
Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -80°C under sterile conditions after reconstitution.
Protein Description
Interleukin 10 (IL-10) is a member of the IL-10 family of α-helical cytokines. IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the expression of a number of proinflammatory cytokines such as IFN- gamma, IL-2, IL-3, TNF and GM-CSF. Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions.
References
Gesser B, et al. (1997) Proc. Natl. Acad. Sci. U.S.A. 94,14620-14625.
Sabat R, et al. (2010) Cytokine Growth Factor Rev. 21,331.
Recombinant Human IL-10
- Product CAT#: HCT-I10-0010 (10ug), HCT-I10-0100 (100ug),HCT-I10-1000 (1000ug)
- Availability: In Stock
Available Options
Tags: Interleukins