Product Application: Recombinant Human IL-2

Primary Application:

Immunotherapy: IL-2 is a potent immunomodulatory cytokine that can enhance immune responses against cancer and viral infections.
Cancer Therapy: It can be used to treat certain types of cancer, such as metastatic melanoma and renal cell carcinoma.
Autoimmune Diseases: IL-2 can be used to treat autoimmune diseases, such as multiple sclerosis.
Vaccinology: IL-2 can be used as an adjuvant to enhance the efficacy of vaccines.

Specific Uses:

Cancer Immunotherapy: IL-2 can be used to stimulate the immune system to attack cancer cells.
Viral Infections: It can be used to enhance the immune response to viral infections.
Autoimmune Diseases: IL-2 can be used to modulate the immune response in autoimmune diseases.
Research: IL-2 is widely used in research to study the immune response and cell signaling pathways.

Key Features and Benefits:

High Purity and Low Endotoxin: Ensures optimal biological activity and minimal side effects.
Recombinant Human IL-2: Guarantees consistent quality and activity.
Easy to Use: Lyophilized format allows for easy storage and reconstitution.
Versatile: Can be used in a variety of applications, including research, pre-clinical, and therapeutic settings.

In summery, Recombinant Human IL-2 is a potent cytokine that stimulates immune responses against cancer and viruses, and modulates autoimmune responses. It's a versatile tool for immunotherapy.

Citations for Recombinant Human IL-2

Welcome to the documentation download page. Below you'll find important documents related to our products, including Certificates of Analysis (COA), Data Sheets, Material Safety Data Sheets (MSDS), and more. These documents provide essential information for product use, safety, and technical specifications.

Product Specifications

Expression of Human Proteins in Human Cells
Extreme low Endotoxin
High Purity
Animal Free and Xeno Free
Tag Free

Source: Human cells derived
Structure: Glycosylated monomer
Purity: >95% by SDS-PAGE
Endotoxin Level: <0.5EU/ug
Molecular Weight: ~15kDa
Formulation: Lyophilized from a 0.2μm filtered solution in PBS without carrier protein

Activity Assay

The specific activity was determined by the dose-dependent stimulation of the proliferation of mouse CTLL-2 cells (mouse cytotoxic T cell line).

Humanized IL-2 (top blue line) activated T cells kill cancer cells compare to Non humanized IL-2 (dark blue line) activated T cells

Reconstitution

Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -80°C under sterile conditions after reconstitution.

Product Description:

Recombinant human IL-2 expressed in engineered human cells. IL-2 belongs to the IL-2 protein family. IL-2 is a 15 kDa glycosylated monomer. IL-2 is produced primarily by activated CD4+ T cells, but it is also expressed by naive CD8+ T cells, eosinophils, dendritic, and thymic cells. IL-2 is an essential activator of the immune response, it is required for the growth of T cells, activated B cells and T helper cell differentiation. IL-2 stimulates the activity of NK cells and is involved in anti-inflammatory reactions and in hematopoiesis.