Product Application: Recombinant Human IL-23
Primary Application:
- Immunology Research: IL-23 is a crucial cytokine involved in the regulation of immune responses, particularly T cell differentiation and activation.
- Autoimmune Disease Research: IL-23 plays a key role in the pathogenesis of autoimmune diseases such as psoriasis and inflammatory bowel disease.
- Cancer Research: IL-23 can influence tumor growth and metastasis.
Specific Uses:
- Drug Discovery: IL-23 can be a target for developing therapies to treat autoimmune diseases.
- Basic Research: IL-23 is used to study the mechanisms of immune responses, inflammation, and autoimmune diseases.
Key Features and Benefits:
- High Purity and Low Endotoxin: Ensures optimal biological activity and minimal off-target effects.
- Recombinant Human IL-23: Guarantees consistent quality and activity.
- Easy to Use: Lyophilized format allows for easy storage and reconstitution.
- Versatile: Can be used in a variety of applications, including research and drug development.
In summery, Recombinant Human IL-23 is a crucial cytokine involved in immune regulation, autoimmune diseases, and cancer. It's used in drug discovery and basic research to study immune responses, inflammation, and autoimmune diseases. However, due to its pro-inflammatory nature, it should be used with caution.
Welcome to the documentation download page. Below you'll find important documents related to our products, including Certificates of Analysis (COA), Data Sheets, Material Safety Data Sheets (MSDS), and more. These documents provide essential information for product use, safety, and technical specifications.
Product Specifications
- Expression of Human Proteins in Human Cells
- Extreme low Endotoxin
- High Purity
- Animal Free and Xeno Free
- Tag Free
Source: Human cells derived
Structure: Glycosylated heterodimer
Purity: >95% by SDS-PAGE
Endotoxin Level: <0.5EU/ug
Molecular Weight: 55kDa
Formulation: Lyophilized from a 0.2μm filtered solution in PBS without carrier protein
Activity Assay
The activity was measured by its ability to induce the IL-17 expression in murine splenocytes.
Reconstitution
Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -80°C under sterile conditions after reconstitution.
Protein Description
IL-23 is a heterodimeric cytokine composed of two subunits: a unique p19 subunit, and a p40 subunit that is shared with IL-12. IL-23 is secreted by activated dendritic cells and macrophages. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T cells and promotes production of proinflammatory cytokines, such as IFNγ and IL-17. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
References
Oppmann B, et al. (2000) Immunity 13,715-725.
Lupardus PJ, et al. (2008) J. Mol. Biol. 382,931-941.
Aggarwal S, et al. (2003) J. Biol. Chem. 278,1910
Recombinant Human IL-23
- Product CAT#: HCT-I23-0010 (10ug), HCT-I23-0100 (100ug), HCT-I23-1000 (1000ug)
- Availability: In Stock
Available Options
Related Products
Recombinant Human IL-6
Product Specifications Expression of Human Proteins in Human Cells Extreme low Endotoxin H..
Recombinant Human IL-12
Product Specifications Expression of Human Proteins in Human Cells Extreme low Endotoxin H..
Tags: Interleukins