Product Application: Recombinant Human IL-6
Primary Application:
- Inflammation: IL-6 is a potent pro-inflammatory cytokine involved in various inflammatory processes.
- Immune Response: It plays a crucial role in the regulation of the immune response, including the differentiation of T cells and B cells.
- Hematopoiesis: IL-6 is involved in hematopoiesis, particularly in the differentiation of megakaryocytes and plasma cells.
Specific Uses:
- Research: IL-6 is widely used in research to study inflammation, immune response, and hematopoiesis.
- Drug Discovery: IL-6 can be a target for drug development to treat inflammatory diseases.
- Clinical Applications: IL-6 can be used in certain clinical settings, such as the treatment of anemia.
Key Features and Benefits:
- High Purity and Low Endotoxin: Ensures optimal biological activity and minimal off-target effects.
- Recombinant Human IL-6: Guarantees consistent quality and activity.
- Easy to Use: Lyophilized format allows for easy storage and reconstitution.
- Versatile: Can be used in a variety of applications, including research, drug development, and diagnostic assays.
In summery, Recombinant Human IL-6 is a potent pro-inflammatory cytokine involved in inflammation, immune response, and hematopoiesis. It's used in research, drug discovery, and clinical applications to study inflammatory processes, immune responses, and hematopoiesis, as well as to develop treatments for inflammatory diseases and anemia.
Citations for Recombinant Human IL-6
Welcome to the documentation download page. Below you'll find important documents related to our products, including Certificates of Analysis (COA), Data Sheets, Material Safety Data Sheets (MSDS), and more. These documents provide essential information for product use, safety, and technical specifications.
Product Specifications
- Expression of Human Proteins in Human Cells
- Extreme low Endotoxin
- High Purity
- Animal Free and Xeno Free
- Tag Free
Source: Human cells derived
Structure: Glycosylated monomer
Purity: >95% by SDS-PAGE
Endotoxin Level: <0.5EU/ug
Molecular Weight: 26-30kDa
Formulation: Lyophilized from a 0.2μm filtered solution in PBS without carrier protein
Activity Assay
The activity was measured by its ability to stimulate the proliferation of human TF-1 cells (human erythroleukemic indicator cell line).
Reconstitution
Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -80°C under sterile conditions after reconstitution.
Protein Description
Human interleukin 6 (IL-6) is a 26-30 kDa glycoprotein with 183 amino acids in length. IL-6 is a pleiotropic cytokine that plays an important role in the final differentiation of B cells into Ig secreting cells. IL-6 acts on B cells, T cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. IL-6 is expressed by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes.
References
Yasukawa, K., et al. (1987) EMBO J. 6, 2939-2945.
Garbers C. et al. (2012) Cytokine Growth Factor Rev. 23:85.
Schwantner A. et al. (2004) J. Biol. Chem.279 (1), 571-576.
Recombinant Human IL-6
- Product CAT#: HCT-I6-0010 (10ug), HCT-I6-0100 (100ug), HCT-I6-1000 (1000ug)
- Availability: In Stock
Available Options
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Tags: Interleukins