Product Application: Recombinant Human Noggin
Primary Application:
- Stem Cell Research: Noggin can be used to maintain the pluripotency of stem cells.
- Developmental Biology: Noggin plays a crucial role in embryonic development, particularly in bone formation and neural development.
- Tissue Engineering: Noggin can be used to modulate cell differentiation and tissue formation.
- Disease Modeling: Noggin can be used to model human diseases associated with dysregulated BMP signaling.
Specific Uses:
- Stem Cell Culture: Noggin can be used to culture and maintain stem cells.
- Drug Discovery: Noggin can be a target for drug development, particularly in the areas of bone diseases and neurodegenerative disorders.
- Research: Noggin is widely used in research to study embryonic development, cell signaling, and tissue regeneration.
Key Features and Benefits:
- High Purity and Low Endotoxin: Ensures optimal biological activity and minimal off-target effects.
- Recombinant Human Noggin: Guarantees consistent quality and activity.
- Easy to Use: Lyophilized format allows for easy storage and reconstitution.
- Versatile: Can be used in a variety of applications, including research, drug development, and tissue engineering.
In summery, Recombinant Human Noggin is a potent signaling molecule that inhibits BMP signaling, playing a crucial role in embryonic development, stem cell biology, and tissue engineering. It's valuable for research, drug discovery, and therapeutic applications. High purity, low endotoxin, and recombinant origin ensure quality and activity. The lyophilized format offers convenience.
Welcome to the documentation download page. Below you'll find important documents related to our products, including Certificates of Analysis (COA), Data Sheets, Material Safety Data Sheets (MSDS), and more. These documents provide essential information for product use, safety, and technical specifications.
Product Specifications
- Expression of Human Proteins in Human Cells
- Extreme low Endotoxin
- High Purity
- Animal Free and Xeno Free
- Tag Free
Source: Human cells derived
Structure: Glycosylated monomer
Purity: >95% by SDS-PAGE
Endotoxin Level: <0.5EU/ug
Molecular Weight: 65kDa
Formulation: Lyophilized from a 0.2μm filtered solution in PBS without carrier protein
Activity Assay
The activity was measured by the inhibition of BMP-4 induced alkaline phosphatase production in the ATDC-5 cell line (Mouse chondrogenic cell line).
Reconstitution
Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -80°C under sterile conditions after reconstitution.
Protein Description
Noggin belongs to a group of diffusible proteins that bind to ligands of the TGF-β family, and regulate their activity by inhibiting their access to signaling receptors. Noggin is expressed in defined areas of the adult central nervous system and peripheral tissues such as lung, skeletal muscle and skin. Noggin has been shown to modulate the activities of other BMPs, which is required for growth and patterning of the neural tube and somite, and essential for cartilage morphogenesis and joint formation. Noggin also inhibits chondrocyte differentiation through its interaction with GDF5.
References
Schwaerzer GK, et al. (2012) J. Bone Miner. Res. 27,429-442.
Groppe J, et al. (2002) Nature 420,636-642.
Brunet LJ, et al. (1998) Science 280,1455
Recombinant Human Noggin
- Brand: StemImmune LLC
- Product CAT#: HST-NG-0010 (10ug), HST-NG-0100 (100ug), HST-NG-1000 (1000ug)
- Availability: In Stock
Available Options
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Tags: Growth Factors