• Recombinant Human PDGFaa

Product Application: Recombinant Human PDGF-aa

Primary Application:

  • Wound Healing: PDGF-aa promotes wound healing by stimulating cell proliferation and migration.
  • Tissue Engineering: PDGF-aa can be used to enhance tissue regeneration and repair.
  • Neurological Disorders: PDGF-aa may have therapeutic potential in neurological disorders, such as stroke and spinal cord injury.
  • Cancer Research: PDGF-aa is involved in tumorigenesis and can be a target for cancer therapy.

Specific Uses:

  • Drug Discovery: PDGF-aa can be a target for drug development to treat wound healing disorders and neurological diseases.
  • Tissue Engineering: PDGF-aa can be used to develop tissue engineering scaffolds and promote tissue regeneration.
  • Research: PDGF-aa is widely used in research to study cell proliferation, migration, and differentiation.

Key Features and Benefits:

  • High Purity and Low Endotoxin: Ensures optimal biological activity and minimal off-target effects.
  • Recombinant Human PDGF-aa: Guarantees consistent quality and activity.
  • Easy to Use: Lyophilized format allows for easy storage and reconstitution.
  • Versatile: Can be used in a variety of applications, including research, drug development, and therapeutic interventions.

In summery, Recombinant Human PDGF-aa is a potent growth factor that plays a crucial role in cell proliferation, migration, and tissue repair. It's involved in wound healing, tissue engineering, neurological disorders, and cancer research. This recombinant protein is valuable for research, drug discovery, and therapeutic applications. High purity, low endotoxin, and recombinant origin ensure quality and activity. The lyophilized format offers convenience.

Welcome to the documentation download page. Below you'll find important documents related to our products, including Certificates of Analysis (COA), Data Sheets, Material Safety Data Sheets (MSDS), and more. These documents provide essential information for product use, safety, and technical specifications.

 

Product Specifications

  • Expression of Human Proteins in Human Cells
  • Extreme low Endotoxin
  • High Purity
  • Animal Free and Xeno Free
  • Tag Free
Source: Human cells derived
Structure: Glycosylated monomer
Purity: >95% by SDS-PAGE
Endotoxin Level: <0.5EU/ug
Molecular Weight: 35, 40, 45kDa

Formulation: Lyophilized from a 0.2μm filtered solution in PBS without carrier protein

Activity Assay

The activity was measured by its ability to stimulate the proliferation of 3T3 cells.

Reconstitution

Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -80°C under sterile conditions after reconstitution.

Protein Description

PDGF is not one molecule but three, each a dimeric combination of two distinct but structurally related peptide chains designated A and B. The dimeric isoforms PDGFaa, ab and bb are differentially expressed in various cell types and their effects are mediated through two distinct receptors, termed α and β. The PDGFs play an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. They are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development.

References

Andrae J, et al. (2008) Genes Dev. 22,1276-1312.
Shim AH, et al. (2010) Proc. Natl. Acad. Sci. U.S.A.107,11307-11312.

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Recombinant Human PDGFaa

  • Brand: StemImmune LLC
  • Product CAT#: HME-Pfa-0010 (10ug), HME-Pfa-0100 (100ug), HME-Pfa-1000 (1000ug)
  • Availability: In Stock

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Tags: Growth Factors