Product application: Recombinant Human Pleiotrophin (PTN)
Key Applications:
- Neurological Research: Studying neuronal growth, differentiation, and plasticity.
- Cancer Research: Investigating the role of PTN in tumor growth and angiogenesis.
- Drug Discovery: Identifying potential therapeutic targets for neurodegenerative diseases and cancer.
- Cell Culture: Promoting cell growth and proliferation in various cell types.
Specific Uses:
- Neurological Research:
- Investigating neurodegenerative diseases like Alzheimer's and Parkinson's
- Studying neural repair and regeneration
- Understanding the mechanisms of neuronal development and plasticity
- Cancer Research:
- Analyzing the role of PTN in tumorigenesis and metastasis
- Identifying potential therapeutic targets for cancer treatment
- Developing novel anti-cancer drugs
Key Features and Benefits:
- High Purity and Low Endotoxin: Ensures optimal biological activity and minimal side effects.
- Animal-Free and Xeno-Free: Eliminates potential contamination and ethical concerns.
- Tag-Free: Preserves the native structure and function of the protein.
- Human Cell-Derived: Provides a more physiologically relevant product.
- Lyophilized Format: Convenient storage and easy reconstitution.
- Extensive Characterization: Rigorously tested for quality and activity.
In summery: Recombinant Human Pleiotrophin (PTN) is a potent growth factor produced in human cells, ensuring high purity, low endotoxin levels, and an animal-free and xeno-free product. It is essential for neural development and has implications in cancer research. This versatile protein is ideal for studying cell growth, differentiation, and signaling pathways, as well as for drug discovery and therapeutic applications.
Welcome to the documentation download page. Below you'll find important documents related to our products, including Certificates of Analysis (COA), Data Sheets, Material Safety Data Sheets (MSDS), and more. These documents provide essential information for product use, safety, and technical specifications.
Please Note: This product's CoA, and Data Sheet are not available.
Product Specifications
- Expression of Human Proteins in Human Cells
- Extreme low Endotoxin
- High Purity
- Animal Free and Xeno Free
- Tag Free
Source: Human cells derived
Structure: Non-glycosylated homodimer
Purity: >95% by SDS-PAGE
Endotoxin Level: <0.5EU/ug
Molecular Weight: 18kDa
Formulation: Lyophilized from a 0.2μm filtered solution in PBS without carrier protein
Activity Assay
The activity was assessed by its ability to promote neurite outgrowth in E16-E18 rat embryonic cortical neurons.
Reconstitution
Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 4 mM HCl containing at least 0.1% human or bovine serum albumin.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -80°C under sterile conditions after reconstitution.
Protein Description
Pleiotrophin (PTN) is a heparin-binding growth factor protein involved in cell development, particularly in the nervous system, where it promotes neuron growth, differentiation, and plasticity. Highly expressed during brain development, PTN also plays a role in cancer, aiding tumor growth and angiogenesis in cancers like glioblastoma and breast cancer. Its interactions with receptors like RPTPβ/ζ activate signaling pathways important for cell survival and proliferation. Because of its roles in neural repair and cancer, PTN is studied as a potential therapeutic target in both regenerative medicine and oncology.
References
Li, Y. S., et al. (1990). Science, 250(4986), 1690–1694.
Ledda, F., et al (2007). Nature Neuroscience, 10(3), 293–300.
Recombinant Human PTN
- Brand: StemImmune LLC
- Product CAT#: HHM-PT-0010 (10ug), HHM-PT-0100 (100ug), HHM-PT-1000 (1000ug)
- Availability: Out Of Stock
Available Options
Related Products
Recombinant Human BMP-4
Product Specifications Expression of Human Proteins in Human Cells Extreme low Endotoxin H..
Heat Stable Recombinant Human FGFbasic
Product Specifications Expression of Human Proteins in Human Cells Extreme low Endotoxin H..
Recombinant Human SCF
Product Specifications Expression of Human Proteins in Human Cells Extreme low Endotoxin H..
Recombinant Human NGF-β
Product Specifications Expression of Human Proteins in Human Cells Extreme low Endotoxin H..
Tags: Growth Factors