Product Application: Recombinant Human GM-CSF

Primary Application:

Hematopoietic Stem Cell Growth and Differentiation: GM-CSF is a potent growth factor that stimulates the proliferation and differentiation of hematopoietic stem cells into various cell types, including granulocytes, macrophages, and erythrocytes.
Immune System Modulation: GM-CSF plays a crucial role in regulating the immune response by stimulating the production of immune cells and enhancing their function.
Tissue Repair and Regeneration: GM-CSF can promote tissue repair and regeneration by stimulating cell proliferation and angiogenesis.

Specific Uses:

Bone Marrow Transplantation: GM-CSF can be used to accelerate hematopoietic recovery after bone marrow transplantation.
Cancer Therapy: It can be used to stimulate the immune system to fight cancer cells.
Infectious Diseases: GM-CSF can be used to treat infections by boosting the immune response.
Research: GM-CSF is widely used in research to study hematopoiesis, immunology, and stem cell biology.

Key Features and Benefits:

High Purity and Low Endotoxin: Ensures optimal biological activity and minimal off-target effects.
Recombinant Human GM-CSF: Ensures consistent quality and activity.
Easy to Use: Lyophilized format allows for easy storage and reconstitution.
Versatile: Can be used in a variety of applications, including research, pre-clinical, and therapeutic settings.

In summary, Recombinant Human GM-CSF is a valuable tool for researchers and clinicians working in the fields of hematology, immunology, and regenerative medicine. It offers a versatile and effective way to manipulate hematopoietic cell development and immune function.

Citations for Recombinant Human GM-CSF

Dendritic Cells Are Critical for the Activation and Expansion of Vδ2+ T Cells After Allogeneic Hematopoietic Transplantation. Front. Immunol., 01 November 2018.

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Product Specifications

Expression of Human Proteins in Human Cells
Extreme low Endotoxin
High Purity
Animal Free and Xeno Free
Tag Free

Source: Human cells derived
Structure: Glycosylated monomer
Purity: >95% by SDS-PAGE
Endotoxin Level: <0.5EU/ug
Molecular Weight: 15-36kDa
Formulation: Lyophilized from a 0.2μm filtered solution in PBS without carrier protein

Activity Assay

The activity was measured by its ability to stimulate the proliferation of human TF-1 cells (human erythroleukemic indicator cell line).

Reconstitution

Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -80°C under sterile conditions after reconstitution.

Protein Description

Granulocyte macrophage colony stimulating factor (GM-CSF) is a cytokine initially characterized by its ability to induce colonies of granulocytes and macrophages from myeloid progenitor cells. It is produced in endothelial cells, monocytes, fibroblasts and T lymphocytes. GM-CSF stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.