• Recombinant Human TGF-β1

Product Application: Recombinant Human TGF-β1

Primary Application:

  • Cell Growth and Differentiation: TGF-β1 plays a crucial role in regulating cell growth, differentiation, and apoptosis.
  • Tissue Repair and Regeneration: TGF-β1 is involved in tissue repair and regeneration processes, including wound healing and fibrosis.
  • Immune Regulation: TGF-β1 is a potent immunosuppressive cytokine that regulates immune responses.
  • Cancer: TGF-β1 has both tumor-suppressive and tumor-promoting activities, depending on the context.

Specific Uses:

  • Research: TGF-β1 is widely used in research to study cell signaling, development, and disease.
  • Drug Discovery: TGF-β1 can be a target for drug development to treat various diseases, including cancer, fibrosis, and autoimmune diseases.
  • Tissue Engineering: TGF-β1 can be used to promote tissue regeneration and repair.

Key Features and Benefits:

  • High Purity and Low Endotoxin: Ensures optimal biological activity and minimal off-target effects.
  • Recombinant Human TGF-β1: Guarantees consistent quality and activity.
  • Easy to Use: Lyophilized format allows for easy storage and reconstitution.
  • Versatile: Can be used in a variety of applications, including research, drug development, and therapeutic interventions.

In summery, Recombinant Human TGF-β1 is a multifunctional cytokine that regulates cell growth, tissue repair, and immune responses. It's a valuable tool for research, drug discovery, and therapy. High purity, low endotoxin, and recombinant origin ensure quality and activity. The lyophilized format is easy to use. However, caution is advised due to its pleiotropic effects.

Welcome to the documentation download page. Below you'll find important documents related to our products, including Certificates of Analysis (COA), Data Sheets, Material Safety Data Sheets (MSDS), and more. These documents provide essential information for product use, safety, and technical specifications.

 

Product Specifications

  • Expression of Human Proteins in Human Cells
  • Extreme low Endotoxin
  • High Purity
  • Animal Free and Xeno Free
  • Tag Free

Source: Human cells derived
Structure: Non-glycosylated homodimer
Purity: >95% by SDS-PAGE
Endotoxin Level: <0.5EU/ug
Molecular Weight: 25kDa
Formulation: Lyophilized from a 0.2μm filtered solution in 10mM NaAoc without carrier protein 

Activity Assay

The activity was measured by its ability to inhibit the IL-4 induced proliferation in mouse HT-2 cells (BALB/c spleen activated by sheep erythrocytes in the presence of IL-2).

Reconstitution

Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 4 mM HCl containing at least 0.1% human or bovine serum albumin.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -80°C under sterile conditions after reconstitution.

Protein Description

Transforming growth factor beta 1(TGF-β1) is one of three closely related mammalian members of the large TGF-β superfamily, TGF-β1, β2, and β3, signal through the same receptor and elicit similar biological responses. TGF-β1 is the most abundant isoform secreted by almost every cell type. TGF-β1 is a multifunctional cytokine that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGF-β1 and have specific receptors for it. TGF-β1 positively and negatively regulates many other growth factors. TGF-β1 plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts.

References

Derynck R, et al. (1985) Nature 316,701-705.
Wah SM , (2006) Immunol. Rev. 213, 213.
Tsang M, et al. (1995) Cytokine 7,389

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Recombinant Human TGF-β1

  • Brand: StemImmune LLC
  • Product CAT#: HST-TB1-0010 (10ug), HST-TB1-0100 (100ug), HST-TB1-1000 (1000ug)
  • Availability: In Stock

Available Options


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Tags: Growth Factor