Product Application: Recombinant Human TPO
Primary Application:
- Hematopoiesis: TPO is a crucial growth factor that stimulates the production of megakaryocytes and platelets.
- Thrombocytopenia: TPO can be used to treat thrombocytopenia, a condition characterized by low platelet counts.
- Stem Cell Research: TPO can be used to culture and expand hematopoietic stem cells.
Specific Uses:
- Drug Discovery: TPO can be a target for drug development to treat thrombocytopenia and other blood disorders.
- Clinical Applications: TPO can be used to treat thrombocytopenia in patients undergoing chemotherapy or bone marrow transplantation.
- Research: TPO is widely used in research to study hematopoiesis and platelet production.
Key Features and Benefits:
- High Purity and Low Endotoxin: Ensures optimal biological activity and minimal off-target effects.
- Recombinant Human TPO: Guarantees consistent quality and activity.
- Easy to Use: Lyophilized format allows for easy storage and reconstitution.
- Versatile: Can be used in a variety of applications, including research, clinical, and therapeutic settings.
In summery, Recombinant Human TPO is crucial for platelet production and treating thrombocytopenia. It's also used in research and stem cell applications. High purity, low endotoxin, and recombinant origin ensure quality and activity. The lyophilized format offers convenience.
Citations for Recombinant Human TPO
- Transient Inhibition of the JNK Pathway Promotes Human Hematopoietic Stem Cell Quiescence and Engraftment. Stem Cells Transl Med. 2022 Jun; 11(6): 597–603.
- Targeting JNK pathway promotes human hematopoietic stem cell expansion. Cell Discovery (2019)5:2
Welcome to the documentation download page. Below you'll find important documents related to our products, including Certificates of Analysis (COA), Data Sheets, Material Safety Data Sheets (MSDS), and more. These documents provide essential information for product use, safety, and technical specifications.
Product Specifications
- Expression of Human Proteins in Human Cells
- Extreme low Endotoxin
- High Purity
- Animal Free and Xeno Free
- Tag Free
Source: Human cells derived
Structure: Glycosylated monomer
Purity: >95% by SDS-PAGE
Endotoxin Level: <0.5EU/ug
Molecular Weight: 80-85kDa
Formulation: Lyophilized from a 0.2μm filtered solution in PBS without carrier protein
Activity Assay
The activity was measured by its ability to stimulate the proliferation of human Mo7e cells.
Reconstitution
Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -80°C under sterile conditions after reconstitution.
Protein Description
Recombinant human thrombopoietin expressed in engineered human cells. TPO belongs to the EPO/TPO protein family. TPO protein is an 80 to 85 kDa monomeric glycoprotein. TPO is primarily produced in the liver and regulates the formation of megakaryocytes and platelets. C terminal domain glycosylation is thought to be important for the secretion of TPO from cells and for survival of TPO in the circulation.
References
Kitamura, T, et al. (1989) J. Cell Physiol. 140, 323-334.
Kaushansky, K, (1998) NEJM 339, 746-754.
Recombinant Human TPO
- Brand: StemImmune LLC
- Product CAT#: HHM-TP-0010 (10ug), HHM-TP-0100 (100ug), HHM-TP-1000 (1000ug)
- Availability: In Stock
Available Options
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