Product Application: Recombinant Human VEGF-165
Primary Application:
- Angiogenesis: VEGF-165 is a potent angiogenic factor that stimulates blood vessel formation.
- Wound Healing: VEGF-165 promotes wound healing by enhancing blood vessel growth and tissue repair.
- Tissue Engineering: VEGF-165 can be used to engineer tissues with a robust vascular network.
- Cancer Research: VEGF-165 is involved in tumor angiogenesis and can be a target for cancer therapy.
Specific Uses:
- Drug Discovery: VEGF-165 can be a target for drug development to treat ischemic diseases and promote tissue regeneration.
- Tissue Engineering: VEGF-165 can be used to enhance tissue engineering strategies.
- Research: VEGF-165 is widely used in research to study angiogenesis, vascular biology, and cancer.
Key Features and Benefits:
- High Purity and Low Endotoxin: Ensures optimal biological activity and minimal off-target effects.
- Recombinant Human VEGF-165: Guarantees consistent quality and activity.
- Easy to Use: Lyophilized format allows for easy storage and reconstitution.
- Versatile: Can be used in a variety of applications, including research, drug development, and therapeutic interventions.
In summery, Recombinant Human VEGF-165 is a potent angiogenic factor involved in blood vessel formation, wound healing, tissue engineering, and cancer. It's used in drug discovery, tissue engineering, and research to study angiogenesis, vascular biology, and cancer.
Citations for Recombinant Human VEGF-165
- VGLL4 promotes vascular endothelium specification via TEAD1 in the vascular organoids and human pluripotent stem cells-derived endothelium model, Cellular and Molecular Life Sciences.19 July 2023
- Chemical reprogramming of human somatic cells to pluripotent stem cells. Nature 2022 May;605(7909):325-331
- Human pluripotent stem cell-derived eosinophils reveal potent cytotoxicity against solid tumors. Stem cell reports. 2021 Jul 13;16(7):1696-1704.
- Genome-wide R-loop Landscapes during Cell Differentiation and Reprogramming. Cell Reports 32 107870, July 7 2020.
- FOXO3-Engineered Human ESC-Derived Vascular Cells Promote Vascular Protection and Regeneration. Cell Stem Cell. Volume 24, Issue 3, 7 March 2019, Pages 447-461.e8
Welcome to the documentation download page. Below you'll find important documents related to our products, including Certificates of Analysis (COA), Data Sheets, Material Safety Data Sheets (MSDS), and more. These documents provide essential information for product use, safety, and technical specifications.
Product Specifications
- Expression of Human Proteins in Human Cells
- Extreme low Endotoxin
- High Purity
- Animal Free and Xeno Free
- Tag Free
Source: Human cells derived
Structure: Glycosylated homodimer
Purity: >95% by SDS-PAGE
Endotoxin Level: <0.5EU/ug
Molecular Weight: 39-45kDa homotrimer
Formulation: Lyophilized from a 0.2μm filtered solution in PBS without carrier protein
Activity Assay
The activity was measured by its ability to stimulate the proliferation of HUVEC cells (Human Umbilical Vein Endothelial Cells).
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Reconstitution
Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -80°C under sterile conditions after reconstitution.
Protein Description
Vascular endothelial growth factor (VEGF) is a potent growth and angiogenic cytokine. It is a member of the PDGF family that is characterized by the presence of eight conserved cysteine residues and a cystine knot structure. Humans express alternately spliced isoforms, and VEGF-165 is the most abundant and potent isoform. VEGF stimulates angiogenesis, vasculogenesis and endothelial cell growth, induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Recombinant human VEGF-165 is a 39-45kDa, disulfide-linked homodimeric protein consisting of two 165 amino acid polypeptides.
References
Leung DW, et al. (1989) Science 246:1306-1309.
Tischer E, et al. (1991) J. Biol. Chem. 266,11947-11954.
Byrne AM, et al. (2005) J. Cell. Mol. Med. 9,777.
Recombinant Human VEGF-165
- Brand: StemImmune LLC
- Product CAT#: HVG-VF5-0010 (10ug), HVG-VF5-0100 (100ug), HVG-VF5-1000 (1000ug)
- Availability: In Stock
Available Options
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Tags: Growth Factors