• Recombinant Human TGF-β1

Product Specifications

  • Expression of Human Proteins in Human Cells
  • Extreme low Endotoxin
  • High Purity
  • Animal Free and Xeno Free
  • Tag Free

Source: Human cells derived
Structure: Non-glycosylated homodimer
Purity: >95% by SDS-PAGE
Endotoxin Level: <0.5EU/ug
Molecular Weight: 25kDa
Formulation: Lyophilized from a 0.2μm filtered solution in PBS without carrier protein 

Activity Assay

The activity was measured by its ability to inhibit the IL-4 induced proliferation in mouse HT-2 cells (BALB/c spleen activated by sheep erythrocytes in the presence of IL-2).

Reconstitution

Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 4 mM HCl containing at least 0.1% human or bovine serum albumin.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -80°C under sterile conditions after reconstitution.

Protein Description

Transforming growth factor beta 1(TGF-β1) is one of three closely related mammalian members of the large TGF-β superfamily, TGF-β1, β2, and β3, signal through the same receptor and elicit similar biological responses. TGF-β1 is the most abundant isoform secreted by almost every cell type. TGF-β1 is a multifunctional cytokine that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGF-β1 and have specific receptors for it. TGF-β1 positively and negatively regulates many other growth factors. TGF-β1 plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts.

References

Derynck R, et al. (1985) Nature 316,701-705.
Wah SM , (2006) Immunol. Rev. 213, 213.
Tsang M, et al. (1995) Cytokine 7,389
Stem Cells Studies
Description Potent stimulator of osteoblastic bone formation
Documentations
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Recombinant Human TGF-β1

  • CAT#: HST-TB1-0010 (10ug), HST-TB1-0100 (100ug), HST-TB1-1000 (1000ug)
  • Availability: In Stock
  • $0.00
  • $-100.00


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