Product Application: Recombinant Human IL-17F
Primary Application:
- Inflammation: IL-17F is a potent pro-inflammatory cytokine that plays a crucial role in the inflammatory response.
- Autoimmune Diseases: It is involved in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and psoriasis.
- Cancer: IL-17F can promote tumor growth and metastasis.
- Research: IL-17F is widely used in research to study inflammation, immune response, and cancer.
Specific Uses:
- Drug Discovery: IL-17F can be used as a target for drug development to treat inflammatory diseases.
- Biomedical Research: IL-17F is used in various biomedical research applications, such as studying the pathogenesis of inflammatory diseases.
Key Features and Benefits:
- High Purity and Low Endotoxin: Ensures optimal biological activity and minimal off-target effects.
- Recombinant Human IL-17F: Guarantees consistent quality and activity.
- Easy to Use: Lyophilized format allows for easy storage and reconstitution.
- Versatile: Can be used in a variety of applications, including research, drug development, and diagnostic assays.
In summery, Recombinant Human IL-17F is a potent pro-inflammatory cytokine involved in inflammation, autoimmune diseases, and cancer. It's used in drug discovery, biomedical research, and as a research tool to study inflammatory processes and immune responses. However, due to its potential to induce inflammation, it should be used with caution.
Welcome to the documentation download page. Below you'll find important documents related to our products, including Certificates of Analysis (COA), Data Sheets, Material Safety Data Sheets (MSDS), and more. These documents provide essential information for product use, safety, and technical specifications.
Product Specifications
- Expression of Human Proteins in Human Cells
- Extreme low Endotoxin
- High Purity
- Animal Free and Xeno Free
- Tag Free
Source: Human cells derived
Structure: Non-glycosylated homodimer
Purity: >95% by SDS-PAGE
Endotoxin Level: <0.5EU/ug
Molecular Weight: 38kDa
Formulation: Lyophilized from a 0.2μm filtered solution in PBS without carrier protein
Activity Assay
The activity was measured by its ability to induce IL-6 expression in the NHDF adult fibroblasts.
Reconstitution
Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -80°C under sterile conditions after reconstitution.
Protein Description
IL-17F is a member of IL-17 family of structurally- related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles. IL-17F is a homodimer of two 133 amino acid chains that are secreted by activated CD4+ T cells and activated monocytes. The biological activities mediated by IL-17F are similar to those of IL-17. IL-17F stimulates the production of other cytokines such as IL-6, IL-8 and granulocyte colony stimulating factor. It can also regulate cartilage matrix turnover, stimulate PBMC and T cell proliferation, and inhibit angiogenesis.
References
Bettelli E, et al. (2008) Nature 453,1051-1057.
Shen F, et al. (2008) Cytokine 41:92.
Starnes T, et al. (2001) J. Immunol. 167,4137- 4140.
Recombinant Human IL-17F
- Product CAT#: HIM-I17f-0010(10ug),HIM-I17f-0100(100ug),HIM-I17f-1000 (1000ug)
- Availability: In Stock
Available Options
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Tags: Interleukins