Product Application: Recombinant Human TGF-β2
Primary Application:
- Cell Growth and Differentiation: TGF-β2 plays a crucial role in regulating cell growth, differentiation, and apoptosis.
- Tissue Repair and Regeneration: TGF-β2 is involved in tissue repair and regeneration processes, including wound healing and fibrosis.
- Immune Regulation: TGF-β2 is a potent immunosuppressive cytokine that regulates immune responses.
- Cancer: TGF-β2 has both tumor-suppressive and tumor-promoting activities, depending on the context.
Specific Uses:
- Research: TGF-β2 is widely used in research to study cell signaling, development, and disease.
- Drug Discovery: TGF-β2 can be a target for drug development to treat various diseases, including cancer, fibrosis, and autoimmune diseases.
- Tissue Engineering: TGF-β2 can be used to promote tissue regeneration and repair.
Key Features and Benefits:
- High Purity and Low Endotoxin: Ensures optimal biological activity and minimal off-target effects.
- Recombinant Human TGF-β2: Guarantees consistent quality and activity.
- Easy to Use: Lyophilized format allows for easy storage and reconstitution.
- Versatile: Can be used in a variety of applications, including research, drug development, and therapeutic interventions.
In summery, TGF-β2 is a multifunctional cytokine regulating cell growth, differentiation, tissue repair, and immune responses. It's valuable for research, drug discovery, and therapy. High purity, low endotoxin, and recombinant origin ensure quality and activity. The lyophilized format is convenient. Use with caution due to pleiotropic effects.
Welcome to the documentation download page. Below you'll find important documents related to our products, including Certificates of Analysis (COA), Data Sheets, Material Safety Data Sheets (MSDS), and more. These documents provide essential information for product use, safety, and technical specifications.
Product Specifications
- Expression of Human Proteins in Human Cells
- Extreme low Endotoxin
- High Purity
- Animal Free and Xeno Free
- Tag Free
Source: Human cells derived
Structure: Non-glycosylated homodimer
Purity: >95% by SDS-PAGE
Endotoxin Level: <0.5EU/ug
Molecular Weight: 25kDa
Formulation: Lyophilized from a 0.2μm filtered solution in 10mM NaAoc without carrier protein
Activity Assay
The activity was measured by its ability to inhibit the IL-4 induced proliferation in mouse HT-2 cells (BALB/c spleen activated by sheep erythrocytes in the presence of IL-2).
Reconstitution
Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 4 mM HCl containing at least 0.1% human or bovine serum albumin.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -80°C under sterile conditions after reconstitution.
Protein Description
Transforming growth factor beta 2 (TGF-β2) is one of three closely related mammalian members of the large TGFβ superfamily, TGF-β1, β2, and β3, signal through the same receptor and elicit similar biological responses. TGF-β2 is expressed in keratinocytes, granulosa cells, astrocytes, osteoblasts, mammary cells, and various cancer cells. TGF-β2 is secreted and complexed with two other proteins, LAP and TGFBP, and requires proteolytic cleavage to be active. Human TGF-β2 is a secreted, homodimer linked by intermolecular disulfide bonds that plays a role in many cellular processes,including embryogenesis and angiostasis. TGF-β2 also plays an extensive role in prenatal development.
References
Derynck R, et al. (1985) Nature 316,701-705.
Sporn MBet al. (2006) Cytokine Growth Factor Rev. 17:3.
Ugo Ripamonti U, et al. (2016) Front. Physiol., 08,396.
Massagué J (2012) Nature Reviews Molecular Cell Biology. 13 (10): 616.
Recombinant Human TGF-β2
- Brand: StemImmune LLC
- Product CAT#: HST-TB2-0010 (10ug), HST-TB2-0100 (100ug), HST-TB2-1000 (1000ug)
- Availability: In Stock
Available Options
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Tags: Growth Factors