Product Application: Recombinant Human TGF-β3
Primary Application:
- Tissue Repair and Regeneration: TGF-β3 plays a crucial role in tissue repair and regeneration, particularly in wound healing and bone formation.
- Immunomodulation: TGF-β3 can modulate the immune response and has anti-inflammatory properties.
- Developmental Biology: TGF-β3 is involved in embryonic development and organogenesis.
Specific Uses:
- Drug Discovery: TGF-β3 can be a target for drug development to treat wound healing disorders and other tissue repair conditions.
- Tissue Engineering: TGF-β3 can be used to promote tissue engineering and regeneration.
- Research: TGF-β3 is widely used in research to study cell signaling, development, and disease.
Key Features and Benefits:
- High Purity and Low Endotoxin: Ensures optimal biological activity and minimal off-target effects.
- Recombinant Human TGF-β3: Guarantees consistent quality and activity.
- Easy to Use: Lyophilized format allows for easy storage and reconstitution.
- Versatile: Can be used in a variety of applications, including research, drug development, and therapeutic interventions.
In summery, TGF-β3 is a multifunctional cytokine that plays a crucial role in tissue repair and regeneration, particularly in wound healing and bone formation. It also modulates the immune response and is involved in developmental processes. This recombinant protein is valuable for research, drug discovery, and tissue engineering. High purity, low endotoxin, and recombinant origin ensure quality and activity. The lyophilized format is convenient. However, due to its pleiotropic effects, it should be used with caution.
Citations for Recombinant Human TGF-β3
Welcome to the documentation download page. Below you'll find important documents related to our products, including Certificates of Analysis (COA), Data Sheets, Material Safety Data Sheets (MSDS), and more. These documents provide essential information for product use, safety, and technical specifications.
Product Specifications
- Expression of Human Proteins in Human Cells
- Extreme low Endotoxin
- High Purity
- Animal Free and Xeno Free
- Tag Free
Source: Human cells derived
Structure: Non-glycosylated homodimer
Purity: >95% by SDS-PAGE
Endotoxin Level: <0.5EU/ug
Molecular Weight: 25kDa
Formulation: Lyophilized from a 0.2μm filtered solution in 10mM NaAoc without carrier protein
Activity Assay
The activity was measured by its ability to inhibit the IL-4 induced proliferation in mouse HT-2 cells (BALB/c spleen activated by sheep erythrocytes in the presence of IL-2).
Reconstitution
Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 4 mM HCl containing at least 0.1% human or bovine serum albumin.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -80°C under sterile conditions after reconstitution.
Protein Description
Transforming growth factor beta 3(TGF β3) is one of three closely related mammalian members of the large TGF β superfamily, TGF-β1, β2, and β3, signal through the same receptor and elicit similar biological responses. The mammalian TGF-β3 controls a vast array of biological processes including immune regulation, cell proliferation, epithelial-mesenchymal transition, and the bone formation. It is generally recognized to facilitate chondrogenic differentiation of precursor cells. It may also have a dose-dependent inhibitory effect on osteogenesis. Recombinant Human TGF-β3 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.
References
Derynck R, et al. (1985) Nature 316,701-705.
Sporn MBet al. (2006) Cytokine Growth Factor Rev. 17:3.
Ugo Ripamonti U, et al. (2016) Front. Physiol., 08,396.
Recombinant Human TGF-β3
- Brand: StemImmune LLC
- Product CAT#: HST-B3-0010 (10ug), HST-B3-0100 (100ug), HST-B3-1000 (1000ug)
- Availability: In Stock
Available Options
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Tags: Growth Factors