Product Application: Recombinant Human IL-17A
Primary Application:
- Inflammation: IL-17A is a potent pro-inflammatory cytokine that plays a crucial role in the inflammatory response.
- Autoimmune Diseases: It is involved in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and psoriasis.
- Cancer: IL-17A can promote tumor growth and metastasis.
- Research: IL-17A is widely used in research to study inflammation, immune response, and cancer.
Specific Uses:
- Drug Discovery: IL-17A can be used as a target for drug development to treat inflammatory diseases.
- Biomedical Research: IL-17A is used in various biomedical research applications, such as studying the pathogenesis of inflammatory diseases.
Key Features and Benefits:
- High Purity and Low Endotoxin: Ensures optimal biological activity and minimal off-target effects.
- Recombinant Human IL-17A: Guarantees consistent quality and activity.
- Easy to Use: Lyophilized format allows for easy storage and reconstitution.
- Versatile: Can be used in a variety of applications, including research, drug development, and diagnostic assays.
In summery, Recombinant Human IL-17A is a potent pro-inflammatory cytokine involved in inflammation, autoimmune diseases, and cancer. It's used in drug discovery, biomedical research, and as a research tool to study inflammatory processes and immune responses.
Welcome to the documentation download page. Below you'll find important documents related to our products, including Certificates of Analysis (COA), Data Sheets, Material Safety Data Sheets (MSDS), and more. These documents provide essential information for product use, safety, and technical specifications.
Product Specifications
- Expression of Human Proteins in Human Cells
- Extreme low Endotoxin
- High Purity
- Animal Free and Xeno Free
- Tag Free
Source: Human cells derived
Structure: Glycosylated monomer
Purity: >95% by SDS-PAGE
Endotoxin Level: <0.5EU/ug
Molecular Weight: 30-35kDa
Formulation: Lyophilized from a 0.2μm filtered solution in PBS without carrier protein
Activity Assay
The activity was measured by its ability to induce IL-6 expression in the NHDF adult fibroblasts.
Reconstitution
Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -80°C under sterile conditions after reconstitution.
Protein Description
IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles. IL-17(IL-17A) is a homodimer of two 136 amino acid chains that are secreted by activated T cells. IL-17A is expressed by activated Th17 cells. IL-17A induces stromal cells to produce proinflammatory and hematopoietic cytokines. It also enhances the surface expression of ICAM1 (intracellular adhesion molecule 1) in fibroblasts.
References
Bettelli E, et al. (2008) Nature 453,1051-1057.
Cua DJ, et al. (2010) Nat. Rev. Immunol. 10, 479.
Fossiez F, et al. (1996) J. Exp. Med. 183, 2593-2603.
Recombinant Human IL-17(IL-17A)
- Brand: StemImmune LLC
- Product CAT#: HIM-I17a-0010(10ug),HIM-I17a-0100(100ug),HIM-I17a-1000 (1000ug)
- Availability: In Stock
Available Options
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Tags: Interleukins