Product Application: Recombinant Human NGF-β
Primary Application:
- Neurotrophic Factor: NGF-β is a crucial neurotrophic factor that supports the survival and differentiation of neurons.
- Pain Management: NGF-β is involved in pain perception and can be used to treat chronic pain.
- Wound Healing: NGF-β promotes wound healing by stimulating cell proliferation and differentiation.
- Neurodegenerative Diseases: NGF-β has potential therapeutic applications in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.
Specific Uses:
- Drug Discovery: NGF-β can be a target for drug development to treat neurodegenerative diseases and chronic pain.
- Tissue Engineering: NGF-β can be used to promote nerve regeneration and tissue repair.
- Research: NGF-β is widely used in research to study neuronal development and function.
Key Features and Benefits:
- High Purity and Low Endotoxin: Ensures optimal biological activity and minimal off-target effects.
- Recombinant Human NGF-β: Guarantees consistent quality and activity.
- Easy to Use: Lyophilized format allows for easy storage and reconstitution.
- Versatile: Can be used in a variety of applications, including research, drug development, and therapeutic interventions.
In summery, Recombinant Human NGF-β is a crucial neurotrophic factor that supports neuronal survival, differentiation, and function. It's involved in pain perception, wound healing, and neurodegenerative disease processes. This recombinant protein is valuable for research, drug discovery, and therapeutic interventions. High purity, low endotoxin, and recombinant origin ensure quality and activity. The lyophilized format offers convenience.
Welcome to the documentation download page. Below you'll find important documents related to our products, including Certificates of Analysis (COA), Data Sheets, Material Safety Data Sheets (MSDS), and more. These documents provide essential information for product use, safety, and technical specifications.
Product Specifications
- Expression of Human Proteins in Human Cells
- Extreme low Endotoxin
- High Purity
- Animal Free and Xeno Free
- Tag Free
Source: Human cells derived
Structure: Glycosylated monomer
Purity: >95% by SDS-PAGE
Endotoxin Level: <0.5EU/ug
Molecular Weight: 13kDa homotrimer
Formulation: Lyophilized from a 0.2μm filtered solution in PBS without carrier protein
Activity Assay
The activity was measured by its ability to stimulate the proliferation of human TF-1 cells (human erythroleukemic indicator cell line).
Reconstitution
Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -80°C under sterile conditions after reconstitution.
Protein Description
Nerve growth factors (NGFs) is composed of three noncovalently linked subunits, α, β, and γ, while the β subunit, called NGF-β exhibits all the biological activities ascribed to NGF. Recombinant human NGF-β is a homodimer of two 120 amino acid polypeptides. NGF-β is important for the development and maintenance of the sympathetic and sensory nervous systems. NGF-β is a well characterized neurotropic protein that plays a critical role in the development of sympathetic and some sensory neurons in the peripheral nervous system. In addition, NGF-β can also act in the central nervous system as a trophic factor for basal forebrain cholinergic neurons. NGF-β has also been shown to have biological effects on non- neuronal tissues.
References
Wijeyewickrema LC, et al. (2010) J. Biol. Chem. 285, 11793-11799.
Cirulli F, et al. (2009) Front. Neuroendo. 30, 379-395.
Recombinant Human NGF-β
- Brand: StemImmune LLC
- Product CAT#: HST-N-0010 (10ug), HST-N-0100 (100ug), HST-N-1000 (1000ug)
- Availability: In Stock
Available Options
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Tags: Growth Factors