Product Application: Recombinant Human HGF
Primary Application:
- Liver Regeneration: HGF is a potent mitogen for hepatocytes and plays a critical role in liver regeneration after injury or disease.
- Wound Healing: HGF promotes wound healing by stimulating cell proliferation and migration.
- Cancer Therapy: HGF has been implicated in tumor growth and metastasis, and it can be used as a target for cancer therapy.
- Stem Cell Research: HGF can be used to induce the differentiation of stem cells into hepatocytes and other cell types.
Specific Uses:
- Liver Disease Treatment: HGF can be used to treat liver diseases, such as liver cirrhosis and liver failure.
- Wound Healing Therapies: HGF can be used in topical treatments to accelerate wound healing.
- Drug Discovery: HGF can be used as a target for drug development, particularly in the areas of liver disease and cancer.
- Research: HGF is widely used in research to study cell proliferation, differentiation, and tissue regeneration.
Key Features and Benefits:
- High Purity and Low Endotoxin: Ensures optimal biological activity and minimal off-target effects.
- Recombinant Human HGF: Ensures consistent quality and activity.
- Easy to Use: Lyophilized format allows for easy storage and reconstitution.
- Versatile: Can be used in a variety of applications, including research, drug development, and clinical therapies.
Summary: Recombinant Human HGF is a valuable tool for researchers and clinicians working in the fields of liver disease, wound healing, and regenerative medicine. It offers a versatile and effective way to manipulate cell growth and tissue regeneration.
Welcome to the documentation download page. Below you'll find important documents related to our products, including Certificates of Analysis (COA), Data Sheets, Material Safety Data Sheets (MSDS), and more. These documents provide essential information for product use, safety, and technical specifications.
Product Specifications
- Expression of Human Proteins in Human Cells
- Extreme low Endotoxin
- High Purity
- Animal Free and Xeno Free
- Tag Free
Structure: Glycosylated monomer
Purity: >95% by SDS-PAGE
Endotoxin Level: <0.5EU/ug
Molecular Weight: 70kDa
Formulation: Lyophilized from a 0.2μm filtered solution in PBS without carrier protein
Activity Assay
The activity was measured by its ability to stimulate the proliferation of the monkey epithelial cell line 4MBr-5.
Reconstitution
Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -80°C under sterile conditions after reconstitution.
Protein Description
HGF is a pleiotropic protein in the plasminogen subfamily of S1 peptidases. HGF is a potent, mesenchymally-derived mitogen for mature parenchymal hepatocytes, and acts as a growth factor for a broad spectrum of tissues and cell types. HGF signals through a transmembrane tyrosine kinase receptor known as MET. Human HGF is secreted as an inactive 728 amino acid (aa) single chain propeptide. HGF regulates many physiological processes including proliferation, scattering, morphogenesis and survival. HGF is a crucial mitogen for liver regeneration processes, especially after partial hepatectomy and other liver injuries.
References
Di Renzo MF, et al. (1991) Oncogene 6, 1997-2003.
Hammond DE, et al. (2004) Curr. Top. Microbiol. Immunol. 286,21.
Bottaro DP, et al. (1991) Science 251,802-804.
Recombinant Human HGF
- Brand: StemImmune LLC
- Product CAT#: HST-HF-0010 (10ug), HST-HF-0100 (100ug), HST-HF-1000 (1000ug)
- Availability: In Stock
Available Options
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Tags: Growth Factors