Product Application: Recombinant Human IGF-1 (E. coli Derived)
Primary Application:
- Cell Growth and Proliferation: IGF-1 is a potent growth factor that stimulates the proliferation and differentiation of various cell types.
- Tissue Repair and Regeneration: It plays a crucial role in tissue repair and regeneration, particularly in muscle and bone.
- Neuroprotection: IGF-1 has neuroprotective effects and can be used to treat neurodegenerative diseases.
- Metabolic Regulation: It regulates glucose metabolism and insulin sensitivity.
Specific Uses:
- Drug Discovery: IGF-1 can be used as a target for drug development, particularly in the areas of aging, neurodegenerative diseases, and metabolic disorders.
- Tissue Engineering: It can be used to enhance tissue regeneration and repair.
- Research: IGF-1 is widely used in research to study cell growth, differentiation, and metabolism.
Key Features and Benefits:
- High Purity and Low Endotoxin: Ensures optimal biological activity and minimal off-target effects.
- Recombinant Human IGF-1: Ensures consistent quality and activity.
- Easy to Use: Lyophilized format allows for easy storage and reconstitution.
- Versatile: Can be used in a variety of applications, including research, drug development, and tissue engineering.
In summery, Recombinant Human IGF-1 is a powerful growth factor that stimulates cell proliferation, differentiation, and tissue repair. It's crucial for neuroprotection, metabolic regulation, and various developmental processes. This recombinant protein is valuable for research, drug discovery, and tissue engineering. High purity, low endotoxin, and recombinant origin ensure quality and activity. The lyophilized format offers convenience.
Welcome to the documentation download page. Below you'll find important documents related to our products, including Certificates of Analysis (COA), Data Sheets, Material Safety Data Sheets (MSDS), and more. These documents provide essential information for product use, safety, and technical specifications.
Source: E. coli derived
Structure: Monomer, with an additional 13 amino acid residues at N terminal.
Purity: >95% by SDS-PAGE
Endotoxin Level: <1EU/ug
Molecular Weight: 9kDa
Formulation: Lyophilized from a 0.2μm filtered solution in 50mM NaAOC without carrier protein
Activity Assay
The activity was measured by its ability to stimulate the proliferation of 3T3 mouse fibroblast cells.
Reconstitution
Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 10mM acetic acid containing 0.1% endotoxin-free recombinant human serum albumin.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -80°C under sterile conditions after reconstitution.
Protein Description
Insulin like growth factor I(IGF-1), also known as somatomedin C, is a secreted protein which belongs to the insulin family. IGF-1 binds IGFI R, IGFII R, and the insulin receptor, although its effects are mediated primarily by IGFI R, which is structurally and functionally related to insulin but has a much higher growth-promoting activity.IGF-1 regulates proliferation and differentiation of a wide variety of cell types. The human mature IGF- 1 composes of 70 amino acids and three disulfide bonds with a MW of 7.6kD. The recombinant IGF- 1 is modified with additional 13 amino acids at N terminal to increase the activity and stability.
References
Ornitz DM, et al. (1996) J. Biol. Chem. 271, 15292- 15297.
Abraham JA, et al. (1986) Cold Spring Harb. Symp. Quant. Biol. 51, 657-668.
Recombinant Human IGF-1
- Brand: StemImmune LLC
- Product CAT#: EME-IF1-0010 (10ug), EME-IF1-0100 (100ug), EME-IF1-1000 (1000ug)
- Availability: In Stock
Available Options
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Tags: Growth Factors