Product Application: Recombinant Human IFN-α2A

Primary Application:

Viral Infections: IFN-α2A is primarily used to treat viral infections, including hepatitis B and C, and certain types of cancer.
Immunomodulation: It can be used to modulate the immune response and treat autoimmune diseases.
Cancer Therapy: IFN-α2A is used in the treatment of certain types of cancer, such as hairy cell leukemia and melanoma.

Specific Uses:

Viral Hepatitis: IFN-α2A is a key treatment for chronic hepatitis B and C infections.
Cancer Treatment: It is used in the treatment of various cancers, including hairy cell leukemia, melanoma, and renal cell carcinoma.
Immunomodulatory Therapy: IFN-α2A can be used to treat certain autoimmune diseases, such as multiple sclerosis.

Key Features and Benefits:

High Purity and Low Endotoxin: Ensures optimal biological activity and minimal side effects.
Recombinant Human IFN-α2A: Guarantees consistent quality and activity.
Easy to Use: Lyophilized format allows for easy storage and reconstitution.
Versatile: Can be used in a variety of applications, including research, clinical, and therapeutic settings.

In summary, Recombinant Human IFN-α2A is a valuable therapeutic agent for the treatment of viral infections, cancer, and autoimmune diseases. It plays a crucial role in modulating the immune response and fighting viral infections.

Welcome to the documentation download page. Below you'll find important documents related to our products, including Certificates of Analysis (COA), Data Sheets, Material Safety Data Sheets (MSDS), and more. These documents provide essential information for product use, safety, and technical specifications.

Product Specifications

Expression of Human Proteins in Human Cells
Extreme low Endotoxin
High Purity
Animal Free and Xeno Free
Tag Free

Source: Human cells derived
Structure: Glycosylated monomer
Purity: >95% by SDS-PAGE
Endotoxin Level: <0.5EU/ug
Molecular Weight: 16kDa
Formulation: Lyophilized from a 0.2μm filtered solution in PBS without carrier protein

Activity Assay

The activity was measured by its ability to stimulate the proliferation of human TF-1 cells (human erythroleukemic indicator cell line).

Reconstitution

Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -80°C under sterile conditions after reconstitution.

Protein Description

The interferon alpha 2A (IFN-α2A) is type I interferon. IFN-α 2A is produced by macrophages, peripheral blood leukocytes and lymphoblastoid cells. Proteins of this family play an important role in inducing non-specific resistance against a broad range of viral infections. IFN-α 2A has wide biological activities ranging as antiproliferation, immunomodulation, and antiviral. IFN-α 2A also affects cell proliferation and modulate immune responses, and regulates expression of MHC class -I antigens.

References

Adolf GR, et al. (1991) Biochem. J. 276,511-518.
Samuel CE, (2001) Clinical Microbiology Reviews,14(4), 778–809.
Bekisz JS, et al. (2010) Pharmaceuticals, 3(4), 994–1015.