• Recombinant Human IL-21

Product Application: Recombinant Human IL-21

Primary Application:

  • Immunotherapy: IL-21 is a potent immunomodulatory cytokine that can enhance immune responses against cancer and viral infections.
  • Cancer Therapy: It can be used to treat various types of cancer, including melanoma and renal cell carcinoma.
  • Autoimmune Diseases: IL-21 can be used to treat autoimmune diseases, such as multiple sclerosis.
  • Vaccinology: IL-21 can be used as an adjuvant to enhance the efficacy of vaccines.

Specific Uses:

  • Cancer Immunotherapy: IL-21 can be used to stimulate the immune system to attack cancer cells.
  • Viral Infections: It can be used to enhance the immune response to viral infections.
  • Autoimmune Diseases: IL-21 can be used to modulate the immune response in autoimmune diseases.
  • Research: IL-21 is widely used in research to study the immune response and cell signaling pathways.

Key Features and Benefits:

  • High Purity and Low Endotoxin: Ensures optimal biological activity and minimal side effects.
  • Recombinant Human IL-21: Guarantees consistent quality and activity.
  • Easy to Use: Lyophilized format allows for easy storage and reconstitution.
  • Versatile: Can be used in a variety of applications, including research, clinical, and therapeutic settings.

in summery, Recombinant Human IL-21 is a potent cytokine with diverse applications in immunotherapy. It can be used to stimulate immune responses against cancer cells, enhance the body's defense against viral infections, and modulate immune responses in autoimmune diseases. This versatile cytokine offers a promising approach to address a wide range of immunological challenges.

Welcome to the documentation download page. Below you'll find important documents related to our products, including Certificates of Analysis (COA), Data Sheets, Material Safety Data Sheets (MSDS), and more. These documents provide essential information for product use, safety, and technical specifications.

 

Product Specifications

  • Expression of Human Proteins in Human Cells
  • Extreme low Endotoxin
  • High Purity
  • Animal Free and Xeno Free
  • Tag Free

Source: Human cells derived
Structure: Glycosylated monomer
Purity: >95% by SDS-PAGE
Endotoxin Level: <0.5EU/ug
Molecular Weight: ~15kDa
Formulation: Lyophilized from a 0.2μm filtered solution in PBS without carrier protein

Activity Assay

The activity was measured by a cell proliferation assay using human N1186 T cells. The ED50 for this effect is about 0.5-5ng/ml. The activity was measured by a cell proliferation assay using human N1186 T cells. The ED50 for this effect is about 0.5-5ng/ml.

Reconstitution

Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin. 

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -80°C under sterile conditions after reconstitution.

Protein Description

IL-21 is a typical family I cytokine with broad pleiotropic actions and is primarily produced by T follicular helper cells, Th17, and natural killer T cells in response to antigenic stimulation. Il-21 generally enhances antigen-specific responses of immune cells. It controls the activation, proliferation, differentiation, cytotoxicity, and survival of various target immune cells.  Additionally, IL-21 promotes the anti-tumor activity of CD8+ T-cells and NK cells. IL-21 elicits its effect through binding to IL-21R, which also contains the gamma chain found in other cytokine receptors such as IL-2, IL-4, IL-7, IL-9 and IL-15. IL-21/IL-21R interaction triggers a cascade of events, which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3. Recombinant Human IL-21 is a 15.4 kDa protein consisting of 132 amino acid residues.

References

Parrish Novak, et al. (2000) Nature 408,57.
Spolski R, et al.(2008) Annu Rev Immunol 26,57.
Mehta DS, et al. (2004) Immune Rev 202,84.

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Recombinant Human IL-21

  • Brand: StemImmune LLC
  • Product CAT#: HCT-I21-0010 (10ug), HCT-I21-0100 (100ug), HCT-I21-1000 (1000ug)
  • Availability: In Stock

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Tags: Interleukins