• Recombinant Human OSM

Product Application: Recombinant Human OSM

Primary Application:

  • Inflammation: OSM is involved in inflammatory responses and can regulate the production of other inflammatory cytokines.
  • Hematopoiesis: OSM can influence hematopoiesis, particularly the differentiation of myeloid cells.
  • Neuroprotection: OSM has neuroprotective effects and can promote neuronal survival.
  • Cancer Biology: OSM can have both tumor-promoting and tumor-suppressing effects, depending on the context.

Specific Uses:

  • Research: OSM is widely used in research to study inflammation, immune response, and cell differentiation.
  • Drug Discovery: OSM can be a target for drug development, particularly in the areas of inflammatory diseases and cancer.
  • Clinical Applications: OSM may have potential therapeutic applications in various diseases, including inflammatory bowel disease and neurodegenerative disorders.

Key Features and Benefits:

  • High Purity and Low Endotoxin: Ensures optimal biological activity and minimal off-target effects.
  • Recombinant Human OSM: Guarantees consistent quality and activity.
  • Easy to Use: Lyophilized format allows for easy storage and reconstitution.
  • Versatile: Can be used in a variety of applications, including research, drug development, and clinical trials.

In summery, Recombinant Human OSM is a versatile cytokine with diverse applications in research and medicine. It plays a key role in inflammation, hematopoiesis, neuroprotection, and cancer biology. Researchers use it to study immune responses and disease mechanisms, while drug developers target it for inflammatory diseases and cancer therapies. Clinically, it shows promise for treating conditions like inflammatory bowel disease and neurodegenerative disorders

Welcome to the documentation download page. Below you'll find important documents related to our products, including Certificates of Analysis (COA), Data Sheets, Material Safety Data Sheets (MSDS), and more. These documents provide essential information for product use, safety, and technical specifications.

 

Product Specifications

  • Expression of Human Proteins in Human Cells
  • Extreme low Endotoxin
  • High Purity
  • Animal Free and Xeno Free
  • Tag Free

Source: Human cells derived
Structure: Glycosylated monomer
Purity: >95% by SDS-PAGE
Endotoxin Level: <0.5EU/ug
Molecular Weight: 30kDa homotrimer
Formulation: Lyophilized from a 0.2μm filtered solution in PBS without carrier protein

Activity Assay

The activity was measured by its ability to stimulate the proliferation of human TF-1 cells (human erythroleukemic indicator cell line).

Reconstitution

Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. In general: 12 months from date of receipt, -20 to -80°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to -80°C under sterile conditions after reconstitution.

Protein Description

Oncostatin M (OSM) is a 30 kDa secreted cytokine belonging to the Interleukin 6 family. OSM inhibits the proliferation of a number of tumor cell lines. It also stimulates proliferation of AIDS-KS cells. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. OSM plays crucial roles in inflammation, neuroprotection, hematopoiesis, metabolism and development.

References

Malik N, et al. (1989) Mol. Cell. Biol. 9, 2847-2853.
Rose TM, et al. (1991) Proc. Natl. Acad. Sci. U.S.A.88,8641-8645.

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Recombinant Human OSM

  • Brand: StemImmune LLC
  • Product CAT#: HST-O-0010 (10ug), HST-O-0100 (100ug), HST-O-1000 (1000ug)
  • Availability: In Stock

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